- Gwynn Murray, Broadway actress
- Joseph R. Sarnoski, Congressional Medal of Honor recipient (World War II)
- Patrick DeLacey, Congressional Medal of Honor recipient (Civil War)
- General Jerome F. O'Malley
- Pennsylvania Governor Robert P. Casey (family from Carbondale Township)
- Pennsylvania State Auditor General Robert Casey, Jr. (family from Carbondale Township)
- The founders of the pharmaceutical company Johnson and Johnson were from Carbondale
- Eli E. Hendrick, industrialist
- Mary B. McAndrew, educator
- Jack Race, author and pilot
- General Alvin Ungerlider
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